Do you have a special type of mouse, or a special configuration for the mouse? I don't really think that should be an issue, but this sounds weird. It also sounds vaguely familiar from a while ago, but I can't really recall for sure.
Have you tried hitting the enter key and/or other keys on the keyboard to do things instead of the mouse? Is your CPU a Dual or Quad Core?
Most importantly, are you running a legal copy of Titanium, or did you download it from somewhere?
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