You might *MIGHT* be able to change class names via the strings files, though I'd put money on many references being hardcoded.
You can change most things about classes, what spells and disciplines they get. Skills are a bit touchy, you can change what level they get them and how high they can be trained but you can't change what skills they get.
You can pretty much change items to do whatever you want aside from letting people without dual wield use two one handed weapons. You could change beastlords into melee oriented plate wearers if you wanted for example.
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