Depends on what you change. For some things you can reload some you can't #reloadstatic and #repop for things you can.
*.eqg and *.s3d containers contain the graphical assets for the game (*.pak too but those are only used for a small fraction of non-zone assets).
There's no way to really do the third thing without either modifying the database or modifying source. Database is the far easier way as it's simply one query.
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