Distros are like flavors of ice cream
Ice creams are almost all built on cream, sugar and cold, and Linux distros are all built on Linus' kernel and the GNU tools. Debian and Fedora (more accurately, Red Hat) are both older, solid distros, and most (not all, but rather most) speciality and beginners' distros are forks or derivations of one of those two. With an everyman's working knowledge of your favorite distro that uses the .deb or .rpm package format, you should be able to adapt one guide or the other to your distro of choice.
If you're not a Linux user and just looking for the advantages of Linux inside a VM, stick to the guides to the letter. Fedora and Debian mainly come down to personal preferences; you won't find great advantages or disadvantages in either against the other.
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