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 If by "big hit" you mean largest playerbase, I think WoW has the advantage over all forthcoming MMOG's.  They have the respect of a large fanbase, much larger than that of EQ.  Sigil, while they may produce a quality game, lacks this fanbase.
 The only way WoW is gonna lose is if the game sucks.  That's a bet I'm not willing to make.  Blizzard writes tight code.
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