yes like kroeg said they can crash with the click of a button. They are freaking agonizing to make and make it work but the rewards are perfect.
What I did was, I had 2 bugs, one a crash in 3 specific zones, and an item disappaer, i fixed item bug, but i realized that the crash for zones was because i f-ed up the quest database on an npc in that zone. I just erased it and it started working again.
Check all things that even might not have anything to do with it. like...datarate is sitting on top, you think its latest, you check other things, and you check that and thats it. Cover all bases.
As I say "I Have the Greatest Weapon of All, My Mind and My Logic"