Try going to your sound options and ensuring your speakers are configured correctly.
On my Vista machine, I couldn't hear sound from certain items. I had to go to the sound properties and set up all aspects of "Speakers". I have logitech speakers with no center channel and it has a subwoofer, but it is not an individual speaker. So I don't really have a 4.1 system but I had to either select "Stereo" or pick 4.1 and disable the center channel and subwoofer.
Also, for a different program, I enabled Sound Mixer which is supposed to be another Realtek problem.
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