I never have any issues with mob spawn timers or anything at all with using Dynamic zones. The only time I use static zones is for zones with special events/scripts in them. Static zones will save the loot tables, as well as script spawned NPCs if you need to do either of those for any particular reason. Overall, I would suggest using Dynamic zones most of the time. As long as your server isn't archaic in it's hardware statistics, dynamic zones load very quickly when needed. For older server hardware, Static is probably a good option for decreasing loading time slightly when no one is in the zone yet.
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